REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE (2)

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EXHIBIT A SCOPE OF WORT{ UNIVERSITY OF CALIFORNIA, IRVINE PROGRAM IN PUBLIC HEALTH SUSAN AND HENRY SAMUELI COLLEGE OF HEALTH SCIENCES TITLE: Seroprevalence Surveillance and Predictive Modeling for COVID-19 in Santa Ana, California PURPOSE I. Understand the cumulative (current and past) incidence of both symptomatic and asymptomatic COVID-19 cases in Santa Ana 2. Describe infected individuals based on geography and demographics of age, gender, and race/ethnicity balanced to Santa Ana population 3. Develop predictive models for COWD-19 in Santa Ana BACKGROUND Santa Ana, a bustling metropolis of 332,725, has experienced someofthe most rapid growth in COVID-19 cases in southern California. The city is 78% LatinX, and almost 20% of residents live at or below poverty level. The community has been disproportionately burdened by the public health threat of COVID-19 with a significant impact of social determinants of health on disparities in incidence and severity. The city is home to a large proportion of essential workers, including first responders such as healthcare workers. We hypothesize that underserved populations living in lower -income census tracts are experiencing a spike in COVID-19 transmission due to increased housing density, employment in "essential/frontline" job sectors, lower educational attainment, and limited health care access. These higher risk individuals could then unknowingly bring the virus home from their workplace to their households, allowing for continued community transmission of COVID-19. Santa Ana is densely populated (12,311.83/sq. mi), few people can work from home, and a significant portion of residents are not insured or under insured. The UCI Program in Public Health is partnering with the city of Santa Ana to conduct COVID-19 serosurveillance of residents and develop predictive models for COVID-19 in the community. UCI PROGRAM IN PUBLIC HEALTH RESEARCH TEAM Team Member Experience Role Bernadette Boden-Albala, Internationally recognized expert in Principal Investigator — Will DrPh, MPH the social epidemiology of stroke and oversee and provide input Professor, Epidemiology cardiovascular disease with an and expertise on all aspects of and Health, Society, and academic background in infectious the study, including sampling Behavior disease epidemiology. Has led plan, survey development, Director and Founding numerous large, multi -site studies in recruitment, logistical Dean, Program in Public urban and rural communities and has a planning, testing, data Health, Susan and Henry wealth of knowledge and experience analysis, and report and Samueli College of Health leading community -level health manuscript development Sciences, University of assessments and interventions, most California, Irvine recently as principal investigator of