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The Village Santa Ana Specific Plan Project <br />A search of Pu Wed shows that there has been a tremendous amount of research on <br />this topic. This graphic is followed by a search of current literature below it. <br />':::SJLT5 Riy YEAR LJ <br />Air Pollutian and Dementia: A Systematic Review- <br />' <br />P5L6rRri, EtrN, Perera 4 Btedh A, Mudwhy L AftteyCk <br />[ike <br />JAlxheime"Die. d6i:IUZD�JAD-1806M. <br />PMID3A776S78 Ff"PMCartiohl. <br />Share <br />RAtKGROLW4D:9oihair pollutionand demerHiaare curren:and growing global issurs-More arm <br />plaumle lidcsbetweeneeposare to specific air pollutants and dementia. 06.1EMYE. Ta <br />19egA— 242R <br />sWarnoGsalryrovW-YVwv+demvGaavwlkhwsPacktathe mida <br />Air Pollution and Dementia <br />Research indicates that lung -term exposure to airborne pollution, partiautarly <br />fIn@ particulata rnafter IPM2.5) and nitrogen dioxide (1y02}r is associated with an <br />increased risk of dementia. Studies have shown that chronic exposure to higher <br />levels of these pollutants can lead to adverse effects on cognitive abilitles and the <br />development of neu rode generative disorders in older adults, 3 + <br />For instance, a study published in Neurology found that high levels of <br />hamocysteine, a protein involved in cardiovascular conditions, enhance the risk of <br />dementia linked to air pollution- Conversaly, high methionine concentrations <br />appear to reduce this risk- 1 Additionally, a systematic review of 53 articles <br />hlghlighteO that Chronic exposure to higher levels of air pollutants IS iassoclated <br />with negative cognitive outcomes and the presence of dernerltia, 3 <br />Moreover, a study conducted by researchers at the University of Southern <br />California reported that living in areas with PM2.5 levels exceeding the <br />Environmental Protection Agency's standard of 12 pglm' near doublers the risk <br />of dementia in older women- This suggests that air pollution could account f-Or <br />approximately 21% of dementia cases globally If the flodings hold true in the <br />broader population. a <br />Scientists are actively Investigating the mechanijSmg through which air pollution <br />affects the brain, While the exact pathways are still being exploredr there Is <br />growing evidence linking air pollution to cognitive decline and neurcdegenerative <br />diseases. 6 a <br />AFpawmetlEPbner. Please rerlry CrhiCti Two. <br />0 raauralogy.arg 0 prnc.nctr.rYm.nlh.gow ■ txncpalbll[haalth.tao... <br />Assoc.alion i Larl-ier... Jur PallLtnnand Oernen;. Ar P-mutrork a latent toy... <br />0 suence.arg a theguarokan.ccm $ thegaardian.com <br />Grain pcllLMr- Eaidence... Ours air polut-on cause ... Hew Gmerria could het... <br />The need for better ;mall particle modeling <br />City of Santa Ana <br />15-2 <br />cont- <br />Page 2 <br />August 2025 <br />13 <br />